Third Pole Therapeutics

Third Pole Therapeutics is a medical technology company based in Waltham, Massachusetts, focused on developing advanced cardiopulmonary therapies. Founded in 2014 by Professor Warren Zapol and his son, the company specializes in inhaled nitric oxide (NO) delivery systems. Their mission is to enhance respiratory care by making inhaled NO more accessible, particularly for underserved and rural communities. The company's flagship product, the eNOfit™ Portable Inhaled Nitric Oxide Delivery System, generates therapeutic NO on-demand from ambient air. This compact, electrically powered device eliminates the need for large gas cylinders, reducing costs and logistical challenges. It is designed for both hospital use and at-home therapy, targeting conditions such as newborn respiratory failure and chronic obstructive pulmonary disease (COPD). Third Pole Therapeutics is committed to improving treatment options for patients with respiratory failure and chronic lung conditions through ongoing clinical trials and innovative technology.